Mamelodi Sundowns will visit Stellenbosch FC in a top-of-the-table clash in Cape Town, while Orlando Pirates aim to end their three-match winless run.
All eyes are on the Downs versus Stellies clash this weekend, with a fixture that has a potential of being the league decider.
Both sides welcome their key players back from the South Africa U20 camp, which was hosted for week.
Sundowns hold a five points advantage on top with Stellies occupying second place. These two sides played a 1-1 draw back in January when they faced each other.
Before this big match on Sunday, Kaizer Chiefs will have a chance to keep their title hopes alive when they face Chippa United in the morning of Saturday at Wolfson Stadium.
Pirates can close the gap on Saturday when they will face Sekhukhune United. The Buccaneers are under massive pressure after failing to collect maximum points in the last three matches.
Saturday fixtures:
10h00: Chippa United vs Kaizer Chiefs
10h00: Royal AM vs Lamontville Golden Arrows
10h:00 SuperSport United vs Cape Town City
10h00: Moroka Swallows vs Polokwane City
12h00: Sekhukhune United vs Orlando Pirates
Sunday fixtures:
10h00: Richards Bay vs TS Galaxy
10h00: AmaZulu FC vs Cape Town Spurs
12h00: Stellenbosch FC vs Mamelodi Sundowns